Nishino H
Department of Physiology, Nagoya City University Medical School, Japan.
Neurosci Res. 1993 Mar;16(3):157-72. doi: 10.1016/0168-0102(93)90120-f.
The objective of neural transplantation is to improve and reconstruct deteriorated brain function through an intracerebral implant of neural or paraneural tissues. In the last decade, basic research in this field has made great progress and brought magnificent results. Recently, the clinical application for treatment of Parkinson's disease has started and some fruitful effects are seen. Neural transplantation, on the other hand, is a useful tool in neurobiology to study the attention attracting themes, i.e., regeneration, development, plasticity, gene expression, neuroimmunology, trophic factor, etc. In this review, the functional recovery, mechanism, trophic factor, and clinical applications will be discussed pertaining to intracerebral grafting of catecholamine producing cells.
神经移植的目的是通过向脑内植入神经组织或神经旁组织来改善和重建受损的脑功能。在过去十年中，该领域的基础研究取得了巨大进展并带来了显著成果。最近，神经移植在帕金森病治疗中的临床应用已经启动，并取得了一些丰硕的成果。另一方面，神经移植是神经生物学中研究诸如再生、发育、可塑性、基因表达、神经免疫学、营养因子等引人关注主题的有用工具。在这篇综述中，将讨论与脑内移植产生儿茶酚胺的细胞相关的功能恢复、机制、营养因子及临床应用。
