Coyaji K, Krishna U, Ambardekar S, Bracken H, Raote V, Mandlekar A, Winikoff B
Department of Obstetrics and Gynaecology, K.E.M. Hospital, Pune, India.
BJOG. 2007 Mar;114(3):271-8. doi: 10.1111/j.1471-0528.2006.01208.x.
The objective of this study was to determine if a repeat dose of misoprostol following mifepristone or a single dose of misoprostol increases the efficacy of medical termination of pregnancy.
Randomised, placebo controlled trial.
K.E.M. Hospital, Pune, India, and the Health Centre, Larsen and Toubro Limited, Mumbai, India.
A total of 300 women seeking an abortion with amenorrhoea of 8 weeks or less. Methods Women were randomised to receive one or two doses of 400 microgram oral misoprostol at the clinic 48 hours after administration of 200 mg mifepristone. Main outcome measure Complete abortion without surgical intervention. Results The repeat administration of misoprostol 400 microgram improved the complete abortion rate from 86 to 92% and significantly reduced the rate of continuing pregnancy from 7 to 1%. Almost all the women who were administered the additional dose of misoprostol were either very satisfied (58%) or satisfied (37%) with the method. Conclusion While an additional oral dose of 400 microgram misoprostol did not significantly increase the rate of complete abortion without surgical intervention, the additional dose did significantly reduce the rate of continuing pregnancies without compromising the acceptability and ease of use of the method.
本研究的目的是确定米非司酮后重复给予米索前列醇或单次给予米索前列醇是否能提高药物流产的效果。
随机、安慰剂对照试验。
印度浦那的K.E.M.医院以及印度孟买的Larsen和Toubro有限公司健康中心。
总共300名停经8周或更短时间寻求堕胎的妇女。方法：在给予200mg米非司酮48小时后，妇女被随机分配在诊所接受一或两剂400微克口服米索前列醇。主要结局指标：无需手术干预的完全流产。结果：重复给予400微克米索前列醇使完全流产率从86%提高到92%，并显著降低持续妊娠率，从7%降至1%。几乎所有接受额外剂量米索前列醇的妇女对该方法非常满意（58%）或满意（37%）。结论：虽然额外口服400微克米索前列醇并没有显著提高无需手术干预的完全流产率，但额外剂量确实显著降低了持续妊娠率，同时不影响该方法的可接受性和易用性。
