Frederiksen Hanne, Rasmussen Salka E, Schrøder Malene, Bysted Anette, Jakobsen Jette, Frandsen Henrik, Ravn-Haren Gitte, Mortensen Alicja
Danish Institute for Food and Veterinary Research, Bygade, Soborg, Denmark.
Br J Nutr. 2007 Jan;97(1):6-10. doi: 10.1017/S0007114507210153.
Tomatoes are rich in lycopene and other carotenoids which have shown beneficial effects on CVD in epidemiological and intervention studies. In the present study the effect of an extract of lycopene-rich tomatoes, Lyc-O-Mato on atherosclerosis was studies in Watanabe Heritable Hyperlipidemic rabbits. The rabbits were fed a control diet, a control diet supplemented with the tomato extract or a control diet supplemented with a mixture of plant oils for 16 weeks. Lycopene was detected only in plasma of rabbits receiving tomato extract. The tomato extract had no effect on cholesterol and triacylglycerol levels measured in total plasma, lipoprotein fractions and on aortic atherosclerosis evaluated biochemically and by microscopy. Oxidation of lipids in unfractionated plasma also was unaffected by the intake of tomato extract. In conclusion, the tomato extract increased plasma levels of lycopene in rabbits, but had no effect on hypercholesterolaemia, oxidation of plasma lipids or aortic atherosclerosis.
番茄富含番茄红素和其他类胡萝卜素，在流行病学和干预研究中，这些物质已显示出对心血管疾病有益的作用。在本研究中，在渡边遗传性高脂血症兔中研究了富含番茄红素的番茄提取物Lyc-O-Mato对动脉粥样硬化的影响。给兔子喂食对照饮食、添加番茄提取物的对照饮食或添加植物油混合物的对照饮食，持续16周。仅在接受番茄提取物的兔子血浆中检测到番茄红素。番茄提取物对总血浆、脂蛋白组分中测量的胆固醇和三酰甘油水平以及通过生化和显微镜评估的主动脉粥样硬化没有影响。未分级血浆中脂质的氧化也不受番茄提取物摄入的影响。总之，番茄提取物可提高兔子血浆中番茄红素的水平，但对高胆固醇血症、血浆脂质氧化或主动脉粥样硬化没有影响。
