Cooper N R
Dept of Immunology, Scripps Research Institute, La Jolla, CA 92037.
Immunol Today. 1991 Sep;12(9):327-31. doi: 10.1016/0167-5699(91)90010-Q.
The success of microorganisms as human pathogens stems partly from their ability to evade recognition and/or avoid destruction by complement and other natural and acquired defense mechanisms. Here, Neil Cooper reviews the various mechanisms that pathogens have evolved to evade the destructive actions of the complement system, with particular emphasis on the many remarkable examples of the duplication of complement-like structural and functional epitopes by microorganisms. Such mimicry not only enables the pathogens to avoid destruction by complement-mediated mechanisms but also, in a number of instances, facilitates infection.
微生物作为人类病原体能够成功，部分原因在于它们有能力逃避补体以及其他天然和后天防御机制的识别和/或破坏。在此，尼尔·库珀综述了病原体为逃避补体系统的破坏作用而进化出的各种机制，特别强调了微生物复制补体样结构和功能表位的众多显著例子。这种模仿不仅使病原体能够避免被补体介导的机制破坏，而且在许多情况下还促进了感染。
