• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Sequences involved in brain-specific in vitro transcription from the core promoter of the mouse myelin basic protein gene.

作者信息

Tamura T, Sumita K, Mikoshiba K

机构信息

Division of Behavior and Neurobiology, National Institute for Basic Biology, Okazaki, Japan.

出版信息

Biochim Biophys Acta. 1991 Dec 2;1129(1):83-6. doi: 10.1016/0167-4781(91)90215-8.

DOI:10.1016/0167-4781(91)90215-8
PMID:1721839
Abstract

In the previous study, we have shown that a short DNA stretch from -35 to -17 in the core promoter of the mouse myelin basic protein (MBP) gene is mainly responsible for brain-specificity in in vitro transcription. In this study, we found from intensive mutation analysis that the TATA-box sequence at -34 is not critical, but sequences downstream from the TATA-box especially around -20 were important for brain-specificity. The existence of a tissue-specific factor for the MBP core promoter different from the TATA-box-binding factor TFIID is implicated.

摘要

相似文献

1
Sequences involved in brain-specific in vitro transcription from the core promoter of the mouse myelin basic protein gene.
Biochim Biophys Acta. 1991 Dec 2;1129(1):83-6. doi: 10.1016/0167-4781(91)90215-8.
2
Core promoter of the mouse myelin basic protein gene governs brain-specific transcription in vitro.小鼠髓鞘碱性蛋白基因的核心启动子在体外调控脑特异性转录。
EMBO J. 1990 Oct;9(10):3101-8. doi: 10.1002/j.1460-2075.1990.tb07507.x.
3
Regulation of brain-specific transcription of the mouse myelin basic protein gene: function of the NFI-binding site in the distal promoter.小鼠髓鞘碱性蛋白基因脑特异性转录的调控：远端启动子中NFI结合位点的功能。
Biochem Biophys Res Commun. 1990 Mar 16;167(2):648-53. doi: 10.1016/0006-291x(90)92074-a.
4
Cell-type specific factors bind to regulatory elements located downstream of the TATA-box element in the mouse myelin basic protein (MBP) gene promoter.
Biochim Biophys Acta. 1998 Jan 21;1395(2):127-34. doi: 10.1016/s0167-4781(97)00184-x.
5
Transcription from a TATA-less promoter requires a multisubunit TFIID complex.来自无TATA框启动子的转录需要一种多亚基TFIID复合物。
Genes Dev. 1991 Nov;5(11):1935-45. doi: 10.1101/gad.5.11.1935.
6
Analysis of transcription control elements of the mouse myelin basic protein gene in HeLa cell extracts: demonstration of a strong NFI-binding motif in the upstream region.
Nucleic Acids Res. 1988 Dec 23;16(24):11441-59. doi: 10.1093/nar/16.24.11441.
7
Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters.果蝇TFIID与许多缺乏TATA框的启动子中存在的保守下游基础启动子元件结合。
Genes Dev. 1996 Mar 15;10(6):711-24. doi: 10.1101/gad.10.6.711.
8
A downstream initiation element required for efficient TATA box binding and in vitro function of TFIID.一种高效结合TATA盒及TFIID体外功能所需的下游起始元件。
Nature. 1990 Nov 1;348(6296):86-8. doi: 10.1038/348086a0.
9
Demonstration of a transcription element in vitro between the capping site and translation initiation site of the mouse myelin basic protein gene.
FEBS Lett. 1991 Mar 11;280(1):75-8. doi: 10.1016/0014-5793(91)80207-j.
10
A TATA-like sequence located downstream of the transcription initiation site is required for expression of an RNA polymerase II transcribed gene.转录起始位点下游的类TATA序列是RNA聚合酶II转录基因表达所必需的。
Genes Dev. 1990 Sep;4(9):1611-22. doi: 10.1101/gad.4.9.1611.

引用本文的文献

1
Genome-wide computational prediction and analysis of core promoter elements across plant monocots and dicots.跨单子叶植物和双子叶植物核心启动子元件的全基因组计算预测与分析
PLoS One. 2013 Oct 29;8(10):e79011. doi: 10.1371/journal.pone.0079011. eCollection 2013.
2
The JC virus minimal core promoter is glial cell specific in vivo.JC病毒最小核心启动子在体内具有神经胶质细胞特异性。
J Virol. 1995 Apr;69(4):2434-42. doi: 10.1128/JVI.69.4.2434-2442.1995.
3
A developmentally regulated DNA-binding protein from mouse brain stimulates myelin basic protein gene expression.
一种来自小鼠大脑的受发育调控的DNA结合蛋白可刺激髓鞘碱性蛋白基因的表达。
Mol Cell Biol. 1993 May;13(5):3103-12. doi: 10.1128/mcb.13.5.3103-3112.1993.
4
A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells.一种来自小鼠大脑的39-kD DNA结合蛋白可刺激少突胶质细胞中髓鞘碱性蛋白基因的转录。
J Cell Biol. 1995 Sep;130(5):1171-9. doi: 10.1083/jcb.130.5.1171.