Wang Limin, Zhao Yiwei, Li Zhong, Guo Yi, Jones Lindsay L, Kranz David M, Mourad Walid, Li Hongmin
Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.
Nat Struct Mol Biol. 2007 Feb;14(2):169-71. doi: 10.1038/nsmb1193. Epub 2007 Jan 14.
'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
“超抗原”(SAgs)通过与MHC和TCR受体同时相互作用触发T细胞的大量激活,从而导致人类疾病。在此,我们展示了超抗原与其两个受体HLA-DR1/HA和TCR之间完整三元复合物的首个晶体结构,分辨率为2.5埃。最引人注目的发现是,与其他超抗原不同,关节炎支原体丝裂原不仅与TCR Vβ直接接触,还与TCR Vα直接接触。