Wake A, Wada J A
Can J Neurol Sci. 1975 Nov;2(4):493-9. doi: 10.1017/s0317167100020631.
Our observaiton of amygdoloid seizure development in cats indicated early afterdischarge propagation into basal cortical areas prior to the development of bifrontal sharp theta discharge. In view of the implied participation of the frontal lobe in amygdaloid kindling, both fractional lesioning and kindling of selective areas were performed. This paper summarizes out stimulation study involving premotor, prefrontal, mesial frontal and orbital cortices. Except for the orbital series which showed a rather strikingly similar pattern of seizure development to that of amygdaloid kindling, all areas showed significantly different features in terms of the speed of seizure development, afterdischarge propagation, fragility of developing seizure, final stage 5 seizure and post-ictal behavior pattern, interictal discharge morphology and propagation, and generalized seizure triggering threshold intensity. All these findings suggest that the frontal lobe participates in, but is not essential for, the amygdaloid seizure development. The results of ongoing fractional lesion series support such a conclusion.
我们对猫杏仁核癫痫发作发展的观察表明，在双侧额叶尖波θ放电出现之前，早期放电后就会传播到基底皮质区域。鉴于额叶在杏仁核点燃中的潜在作用，我们进行了部分损伤和选择性区域点燃实验。本文总结了我们对运动前区、前额叶、额叶内侧和眶额皮质的刺激研究。除了眶额系列实验显示出与杏仁核点燃非常相似的癫痫发作发展模式外，所有区域在癫痫发作发展速度、放电后传播、发作发展的脆弱性、最终5期发作和发作后行为模式、发作间期放电形态和传播以及全身性癫痫发作触发阈值强度方面都表现出显著不同的特征。所有这些发现表明，额叶参与但并非杏仁核癫痫发作发展所必需。正在进行的部分损伤系列实验结果支持这一结论。
