Wada J A, Mizoguchi T, Komai S
Epilepsia. 1985 Sep-Oct;26(5):472-9. doi: 10.1111/j.1528-1157.1985.tb05683.x.
Despite ready bilateralization of ictal and interictal EEG discharge throughout cortical kindling, the rate of convulsive seizure development was slow at both orbital and mesial frontal sites, even in the epileptic baboon. However, convulsive generalization occurred swiftly from the mesial frontal cortical (MF) sites once conjugate head, eye, and body adversion developed in the three primate species examined. Only epileptic baboons developed Stage 5 bisymmetrical and bisynchronous convulsion. Stimulation of the contralateral homotopic mesial cortical site readily produced afterdischarge that remained localized and convulsive seizure development did not occur. The findings suggest that (a) the frontal lobe plays an important role in the generation of nonconvulsive seizures, (b) the frontorolandic cortex plays a unique role in convulsive seizure generalization, (c) the role of the intrinsic (genetic) factor is significant in determining the quality of the kindled seizure, and (d) the development of focal epileptogenesis at one MF site interferes with clinical seizure development at the "mirror focus." Our findings underscore (a) the necessity of the conceptual differentiation between the EEG mirror focus and the epileptogenic focus capable of generating clinical seizures and (b) the importance of dissecting interictal behavior reflecting a "continuous disorder of neuronal function," which may cause symptoms other than seizures.
尽管在整个皮层点燃过程中发作期和发作间期脑电图放电都能顺利双侧化，但即使在癫痫狒狒中，眶部和内侧额叶部位的惊厥性发作发展速度也很慢。然而，在检查的三种灵长类动物中，一旦出现共轭性头部、眼睛和身体扭转，惊厥性发作就会迅速从内侧额叶皮层（MF）部位泛化。只有癫痫狒狒发展为5期双侧对称和同步惊厥。刺激对侧同位内侧皮层部位很容易产生后放电，后放电局限于该部位，未出现惊厥性发作发展。这些发现表明：（a）额叶在非惊厥性发作的产生中起重要作用；（b）额颞叶皮层在惊厥性发作泛化中起独特作用；（c）内在（遗传）因素在决定点燃性发作的性质方面具有重要意义；（d）一个MF部位的局灶性癫痫发生发展会干扰“镜像灶”的临床发作发展。我们的发现强调了：（a）在脑电图镜像灶和能够产生临床发作的致痫灶之间进行概念区分的必要性；（b）剖析反映“神经元功能持续紊乱”的发作间期行为的重要性，这种紊乱可能导致除发作之外的其他症状。
