[经肾气体灌注保存的肾脏中溶酶体和过氧化物酶体膜的不稳定化]
[Labilization of lysosomal and peroxisomal membranes in the kidneys preserved by transrenal gas perfusion].
作者信息
Panchenko L F, Asoian G A, Gerasimov A M, Komarov O S, Ushenkova L N
出版信息
Vopr Med Khim. 1976 Nov-Dec;22(6):778-84.
The total, free and unprecipitated activity of lysosomal (acid DNAase, acid RNAase, acid phosphate, acid beta-galactosidase) and peroxisomal (catalase, oxidase of D-amino acids) enzymes were studied in dog kidney cortex during storage of the tissues in solution of rheopolyglucin and under conservation of the kidney tissue by transrenal gas perfusion in hypothermia within 3 and 7 days. Labilization of lysosomal and peroxisomal membranes was observed during storage both in unperfused and in oxygenated kidney. Mechanisms of formation and functional significance of the alterations observed in structure of lysosomes and peroxisomes are discussed.
在狗肾皮质组织于低分子右旋糖酐溶液中储存期间以及在低温下通过经肾气体灌注保存肾组织3天和7天的过程中，研究了溶酶体（酸性DNA酶、酸性RNA酶、酸性磷酸酶、酸性β-半乳糖苷酶）和过氧化物酶体（过氧化氢酶、D-氨基酸氧化酶）酶的总活性、游离活性和未沉淀活性。在未灌注和充氧的肾脏储存期间均观察到溶酶体和过氧化物酶体膜的不稳定。讨论了溶酶体和过氧化物酶体结构改变的形成机制及其功能意义。
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