Drozhennikov V A, Perevezentseva O S
Biull Eksp Biol Med. 1980 Jun;89(6):715-6.
Activity of the lysosomal hydrolases DNAase II, acid RNAase and acid phosphatase was studied in the mouse liver and spleen under developing Friend's viral leukemia. The activity of DNAase II in the liver was considerably increased from the 12th day after inoculation of virus-containing material and reached the maximum by the 20th day of the experiment. The activity of acid phosphatase was changed insignificantly while that of acid RNAase showed no deviations from the control level. A possible role of the lysosomal hydrolases in leukemia development is discussed.
在Friend病毒白血病发展过程中，对小鼠肝脏和脾脏中的溶酶体水解酶脱氧核糖核酸酶II、酸性核糖核酸酶和酸性磷酸酶的活性进行了研究。接种含病毒物质后第12天，肝脏中脱氧核糖核酸酶II的活性显著增加，并在实验第20天达到最大值。酸性磷酸酶的活性变化不明显，而酸性核糖核酸酶的活性与对照水平无偏差。文中讨论了溶酶体水解酶在白血病发展中的可能作用。
