Jenkinson David McEwan, Elder Hugh Y, Bovell Douglas L
Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK.
Vet Dermatol. 2007 Feb;18(1):2-11. doi: 10.1111/j.1365-3164.2007.00571.x.
The condition of anhidrosis is described in this review, and the latest theories on the causal factors are explored. The evidence supports the hypothesis that anhidrosis is an inappropriate response to prolonged climatic stress (generally combined heat and high humidity), which can be evoked in a small (approximately 10 +/- 5%) proportion of the equine population. It is caused by gradual failure of the glandular secretory cell processes, initiated by desensitization and subsequent down-regulation of the cell receptors as a result of continued adrenaline-driven hyperactivity. It progresses through secretory failure and culminates in gradual, probably irreversible, glandular dedifferentiation and ultimate degeneration. There is a need for considerably more research on the secretory and transcriptional processes to document the changes arising within the glandular secretory mechanism as a prelude to development of a corrective treatment.
本文综述了无汗症的情况，并探讨了关于其病因的最新理论。有证据支持这样的假说：无汗症是对长期气候应激（通常是高温和高湿相结合）的不适当反应，在一小部分（约10±5%）马属动物中可能会引发。它是由腺分泌细胞过程的逐渐衰竭引起的，这一过程始于脱敏，随后由于持续的肾上腺素驱动的过度活跃导致细胞受体下调。它通过分泌功能衰竭发展，最终导致腺体逐渐的、可能不可逆转的去分化和最终退化。需要对分泌和转录过程进行更多研究，以记录腺分泌机制内发生的变化，为开发纠正性治疗方法做准备。
