Senbanjo Richard, Wolff Kim, Marshall Jane
East Kent Community Drug Service, KCA, Ashford, Kent, UK.
Addiction. 2007 Feb;102(2):257-63. doi: 10.1111/j.1360-0443.2006.01683.x.
To evaluate the impact of excessive alcohol consumption on the health-related quality of life of patients receiving methadone treatment for opioid dependence.
A cross-sectional survey.
One hundred and ninety-two patients attending out-patient methadone clinics in the south-east of England, United Kingdom.
Quality of life (QoL) was assessed using the Medical Outcomes Study: General Health Survey, Short Form (SF-12). Alcohol consumption was assessed using the Alcohol Use Disorders Identification Test (AUDIT).
Approximately one-third of the sample (57/192) were AUDIT-positive (score > or = 8) and 20 of the 135 AUDIT-negative patients reported past history of alcohol problems. AUDIT-positive patients were less satisfied with their methadone dose than AUDIT-negative patients (P = 0.002), despite having a higher dose. AUDIT-positive patients reported more physical (P = 0.020) and psychological (P = 0.034) health problems and poorer QoL (P = 0.008) with an estimated effect size of 0.46. Lower QoL scores for AUDIT-positive patients affected both 'physical' (P = 0.009) and 'psychological' (P = 0.012) health domains with poor role functioning ('role limitation' due to physical health, P < 0.001 and to emotional health, P = 0.009), social functioning (P = 0.015) and self-perceived general health (P = 0.029).
Excessive alcohol consumption may be associated with a distinctive pattern of QoL impairment in methadone patients. In addition to advising methadone patients regarding their alcohol consumption, comprehensive care plans should seek to restore normal personal, family and social role functioning through the provision of appropriate health and social care.
评估过量饮酒对接受美沙酮治疗阿片类药物依赖患者健康相关生活质量的影响。
横断面调查。
英国英格兰东南部门诊美沙酮诊所的192名患者。
使用医学结果研究简表健康调查（SF - 12）评估生活质量（QoL）。使用酒精使用障碍识别测试（AUDIT）评估饮酒情况。
约三分之一的样本（57/192）AUDIT呈阳性（得分≥8），135名AUDIT阴性患者中有20名报告有饮酒问题史。AUDIT阳性患者对美沙酮剂量的满意度低于AUDIT阴性患者（P = 0.002），尽管前者剂量更高。AUDIT阳性患者报告有更多的身体（P = 0.020）和心理（P = 0.034）健康问题以及较差的生活质量（P = 0.008），估计效应大小为0.46。AUDIT阳性患者较低的生活质量得分影响了“身体”（P = 0.009）和“心理”（P = 0.012）健康领域，包括角色功能不佳（因身体健康导致的“角色限制”，P < 0.001；因情绪健康导致的“角色限制”，P = 0.009）、社会功能（P = 0.015）和自我感知的总体健康（P = 0.029）。
过量饮酒可能与美沙酮患者独特的生活质量受损模式相关。除了就饮酒问题向美沙酮患者提供建议外，综合护理计划应通过提供适当的健康和社会护理来努力恢复正常的个人、家庭和社会角色功能。
