Shubik P
Cancer Res. 1975 Nov;35(11 Pt. 2):3475-80.
The potential role in carcinogenesis of food additives and contaminants presents a complex problem in terms of assessing the risk to the general public. Long-term testing in laboratory animals is still the most feasible method for determining potential carcinogenicity of various chemicals. The disadvantages encountered in the present methods of animal testing are discussed and a review is made of the current status of particular food additives and contaminants under scrutiny as possible carcinogens. It is suggested that, since it may not be possible to remove all carcinogenic materials from the environment, methods to mitigate or neutralize their harmful effects should be sought. Greater cooperation is called for among food technologists, toxicologists, laboratory researchers, and epidemiologists in the decision-making process regarding the role of possibly carcinogenic additives and contaminants.
食品添加剂和污染物在致癌过程中的潜在作用，在评估对公众的风险方面是一个复杂的问题。对实验动物进行长期测试仍然是确定各种化学物质潜在致癌性最可行的方法。文中讨论了当前动物测试方法中遇到的缺点，并综述了作为可能致癌物而受到审查的特定食品添加剂和污染物的现状。建议由于可能无法从环境中去除所有致癌物质，因此应寻求减轻或中和其有害影响的方法。在关于可能致癌的添加剂和污染物的作用的决策过程中，食品技术专家、毒理学家、实验室研究人员和流行病学家之间需要加强合作。
