维生素A缺乏对大鼠肝脏和结肠环氧化物水解酶的影响。
Effect of vitamin A deficiency on rat hepatic and colon epoxide hydrase.
作者信息
Adekunle A A, Campbell T C, Campbell S C
出版信息
Experientia. 1979 Feb 15;35(2):241-2. doi: 10.1007/BF01920640.
PMID:421845
Abstract
Rat liver microsomes and homogenized mucosal linings prepared from vitamin A-supplemented and deficient male rats were used in metabolic studies of 7-3H-styrene oxide. The colon tissue in deficient animals exhibits a significantly higher value of Vmax than the same tissue from vitamin-supplemented animals. The implications of this finding in addition to our earlier observation 10 is discussed in relation to colon carcinoma.
摘要
从补充维生素A和缺乏维生素A的雄性大鼠制备的大鼠肝微粒体和匀浆粘膜内衬用于7-³H-苯乙烯氧化物的代谢研究。缺乏维生素A的动物的结肠组织比补充维生素的动物的相同组织表现出显著更高的Vmax值。结合结肠癌讨论了这一发现以及我们早期观察结果的意义。
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