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人血清样本中溶血磷脂酶D/自分泌运动因子活性的测定。

Measurement of lysophospholipase D/autotaxin activity in human serum samples.

作者信息

Nakamura Kazuhiro, Ohkawa Ryunosuke, Okubo Shigeo, Tozuka Minoru, Okada Mitsumasa, Aoki Shinya, Aoki Junken, Arai Hiroyuki, Ikeda Hitoshi, Yatomi Yutaka

机构信息

Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.

出版信息

Clin Biochem. 2007 Feb;40(3-4):274-7. doi: 10.1016/j.clinbiochem.2006.10.009. Epub 2006 Oct 19.

DOI:10.1016/j.clinbiochem.2006.10.009
PMID:17222397
Abstract

OBJECTIVES

Lysophospholipase D (lysoPLD)/autotaxin regulates the blood levels of lysophosphatidic acid (LPA), and we designed a serum lysoPLD assay for use in clinical laboratory testing.

DESIGN AND METHODS

LysoPLD activity was assessed based on the amount of choline released with lysophosphatidylcholine as the substrate.

RESULTS AND CONCLUSIONS

It was confirmed that the lysoPLD assay can be applied to clinical laboratory testing. The serum lysoPLD activity in healthy female subjects was significantly higher than that in the male subjects.

摘要

目的

溶血磷脂酶D（lysoPLD）/自分泌运动因子调节溶血磷脂酸（LPA）的血液水平，我们设计了一种用于临床实验室检测的血清lysoPLD检测方法。

设计与方法

基于以溶血磷脂酰胆碱为底物释放的胆碱量评估lysoPLD活性。

结果与结论

证实lysoPLD检测方法可应用于临床实验室检测。健康女性受试者的血清lysoPLD活性显著高于男性受试者。

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