Mackenzie I C, Rittman G, Gao Z, Leigh I, Lane E B
University of Texas Health Science Center, Houston Dental Branch/Dental Science Institute.
J Periodontal Res. 1991 Nov;26(6):468-78. doi: 10.1111/j.1600-0765.1991.tb01797.x.
Specimens of human gingiva were collected from teenage and adult subjects and frozen sections were stained with an extensive panel of monoclonal antibodies with defined specificities for individual cytokeratins. The results indicated different and distinctive patterns of keratin expression by the oral gingival, oral sulcular and the junctional epithelia. It was observed that epithelium with staining characteristics of sulcular epithelium extended over the gingival crest onto the oral surface of the gingiva. Junctional epithelium showed the unusual pattern of co-expression of keratins typical of the stratifying and of the simple epithelial phenotypes. The patterns of gingival keratin expression are compared with those of other mucosal epithelia. The findings are discussed in relation to mechanisms that may determine or influence the junctional epithelial phenotype.
从青少年和成年受试者身上采集人牙龈样本，将冰冻切片用一系列针对单个细胞角蛋白具有明确特异性的单克隆抗体进行染色。结果表明，口腔牙龈上皮、口腔龈沟上皮和结合上皮的角蛋白表达模式不同且具有独特性。观察到具有龈沟上皮染色特征的上皮延伸至牙龈嵴，直至牙龈的口腔表面。结合上皮呈现出典型的分层上皮和简单上皮表型的角蛋白共表达的异常模式。将牙龈角蛋白表达模式与其他黏膜上皮的模式进行了比较。结合可能决定或影响结合上皮表型的机制对这些发现进行了讨论。
