Li Dawei, He Lin
Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China.
Genet Med. 2007 Jan;9(1):4-8. doi: 10.1097/01.gim.0000250507.96760.4b.
Schizophrenia is a severe mental illness to which hypofunction of the N-methyl-D-aspartate receptors has been linked. Association studies have implicated the N-methyl-D-aspartate receptor 2B subunit gene (GRIN2B) as a candidate for schizophrenia. Subsequent studies have attempted to replicate the association, but the results have been mixed and thus inconclusive. It is necessary to explain the inconsistency of these results and to clarify the contribution of the GRIN2B gene to schizophrenia. The current meta-analysis covers all published association studies up to January 2006 using systematic allelic and genotypic analyses involving five polymorphisms. The results show evidence of a statistically significant association for GRIN2B. The association seems weaker, but nonetheless interesting. The meta-analysis supports the involvement of the glutamate system of the brain in the pathogenesis of schizophrenia. This may be the first systematic meta-analysis study focusing on GRIN2B.
精神分裂症是一种严重的精神疾病，N-甲基-D-天冬氨酸受体功能减退与之相关。关联研究已将N-甲基-D-天冬氨酸受体2B亚基基因（GRIN2B）作为精神分裂症的一个候选基因。后续研究试图重复这种关联，但结果不一，因此尚无定论。有必要解释这些结果的不一致性，并阐明GRIN2B基因对精神分裂症的作用。当前的荟萃分析涵盖了截至2006年1月所有已发表的关联研究，采用了涉及五种多态性的系统等位基因和基因型分析。结果显示GRIN2B存在统计学上显著关联的证据。这种关联似乎较弱，但仍然很有意思。荟萃分析支持大脑谷氨酸系统参与精神分裂症的发病机制。这可能是第一项聚焦于GRIN2B的系统性荟萃分析研究。
