Nakao A, Virji A, Iwaki Y, Carr B, Iwatsuki S, Starzl E
Department of Surgery, University of Pittsburgh School of Medicine.
Hepatogastroenterology. 1991 Oct;38(5):450-3.
Des-gamma-carboxy prothrombin (DCP), a protein induced by vitamin K absence or antagonist-II (PIVKA-II) was measured by an enzyme immunoassay (E-1023) using anti-DCP monoclonal antibody in 92 patients with various hepatobiliary diseases. Thirty-six of the 38 patients (94.7%) with hepatocellular carcinoma (HCC) had abnormal DCP levels greater than 0.1 arbitrary unit (AU)/ml, but only 18 of the 35 patients (51.4%) had AFP greater than 100 ng/ml (suspicious levels for HCC). There was no correlation between plasma or serum DCP and serum alpha-fetoprotein (AFP) levels. Serum alpha fetoprotein was elevated (above 20 ng/ml) in 23 of the 35 patients (65.7%), and DCP was elevated in all of the remaining 12 patients with normal AFP. DCP levels returned to normal levels following curative hepatic resection or orthotopic liver transplantation for HCC. DCP is a useful tumor marker in the diagnosis and postoperative monitoring of patients with HCC.
采用抗去γ-羧基凝血酶原（DCP）单克隆抗体的酶免疫测定法（E-1023），对92例各种肝胆疾病患者检测了维生素K缺乏或拮抗剂-II诱导蛋白（PIVKA-II，即DCP）。38例肝细胞癌（HCC）患者中有36例（94.7%）DCP水平异常，高于0.1任意单位（AU）/ml，但35例患者中只有18例（51.4%）甲胎蛋白（AFP）大于100 ng/ml（HCC可疑水平）。血浆或血清DCP与血清甲胎蛋白（AFP）水平之间无相关性。35例患者中有23例（65.7%）血清甲胎蛋白升高（高于20 ng/ml），其余12例AFP正常的患者DCP均升高。对HCC进行根治性肝切除或原位肝移植后，DCP水平恢复正常。DCP是HCC患者诊断和术后监测的有用肿瘤标志物。
