[信号转导和转录激活因子3、信号转导和转录激活因子5、生存素及Ki67在鼻NK/T细胞淋巴瘤中的表达及其意义]

[Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma].

作者信息

Yue Lihua, Cheng Jinmei, Zhang Peng fei, Lin Gongbiao, Yi Zixiang, Zhang Rong

机构信息

Fujian Institute of Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.

出版信息

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Oct;20(20):931-3, 936.

PMID:17225522

Abstract

OBJECTIVE

To study the expression and its significance of STAT3, STAT5, Survivin and Ki67 in the Epstein-Barr virus associated nasal NK/T cell lymphoma.

METHOD

The expression of STAT3, STAT5, Survivin and Ki67 were detected with immunohistochemistry in 25 cases of nasal NK/T cell lymphoma, and their relationship was analyzed. Nasal cavity tissues from 20 cases of chronic sinusitis were as the control group.

RESULT

The positive rates of STAT3 in the lymphoma and in control group were 56% and 10%, respectively (P <0.01). The positive rates of STAT5 in the lymphoma and in control group were 68% and 15%, respectively (P <0.01). The positive rates of Survivin and Ki67 of nasal NK/T cell-lymphoma were 68% and 72%, respectively; but it in the control group was 0% and 20%, respectively, P <0.01. The expression of STAT3 was positively related to that of Survivin and Ki67(r =0. 428, P <0. 05 and r =0. 704, P <0. 01); The expression of STAT5 was not related to that of Survivin and Ki67.

CONCLUSION

The pathway of STAT may play a role in the development of nasal NK/T cell lymphoma. STAT maybe take part in the formation of nasal NK/T cell lymphoma through induction of Survivin and Ki67.

摘要

目的

研究信号转导和转录激活因子3（STAT3）、信号转导和转录激活因子5（STAT5）、生存素（Survivin）及Ki67在爱泼斯坦-巴尔病毒相关鼻NK/T细胞淋巴瘤中的表达及其意义。

方法

采用免疫组织化学法检测25例鼻NK/T细胞淋巴瘤中STAT3、STAT5、Survivin及Ki67的表达，并分析其相关性。选取20例慢性鼻窦炎患者的鼻腔组织作为对照组。

结果

淋巴瘤组和对照组中STAT3的阳性率分别为56%和10%（P<0.01）。淋巴瘤组和对照组中STAT5的阳性率分别为68%和15%（P<0.01）。鼻NK/T细胞淋巴瘤中Survivin和Ki67的阳性率分别为68%和72%；而对照组中分别为0%和20%，P<0.01。STAT3的表达与Survivin和Ki67的表达呈正相关（r=0.428，P<0.05；r=0.704，P<0.01）；STAT5的表达与Survivin和Ki67的表达无相关性。