Shibata T, Kono T, Tanii T, Mizuno N, Hamada T
Osaka Prefectural Institute of Public Health, Japan.
Am J Chin Med. 1991;19(3-4):243-9. doi: 10.1142/S0192415X91000326.
The effects of Ryo-kan-kyomi-sin-ge-nin-to (RKSG)) extract, a medicinal agent traditionally used in China and Japan for treatment of asthma, on the degranulation of and histamine release from rat mast cells were studied. At a concentration of 5 mg/ml RKSG, degranulation of mast cells stimulated either by antigen (DNP-Ascaris) or compound 48/80 was markedly suppressed. At a concentration of 1-5 mg/ml RKSG, histamine release from mast cells due to application of either antigen or compound 48/80 was inhibited in a dose-dependent fashion. These results suggest that RKSG may be useful for the treatment of type I allergy-related diseases.
研究了在中国和日本传统上用于治疗哮喘的药物“六君子汤提取物（RKSG）”对大鼠肥大细胞脱颗粒和组胺释放的影响。在浓度为5mg/ml的RKSG作用下，由抗原（二硝基苯基-蛔虫）或化合物48/80刺激引起的肥大细胞脱颗粒受到显著抑制。在浓度为1-5mg/ml的RKSG作用下，由于应用抗原或化合物48/80导致的肥大细胞组胺释放呈剂量依赖性受到抑制。这些结果表明，RKSG可能对治疗I型过敏相关疾病有用。
