仙青龙胆汤提取物对大鼠肥大细胞脱颗粒和组胺释放的抑制作用。

Inhibitory effect of xian-qing-long-tan extract on degranulation and histamine release from rat mast cells.

作者信息

Matsumoto T, Ishida M, Makino M, Shibata T, Ogino S, Matsunaga T

机构信息

Department of Otorhinolaryngology, Osaka Prefectural Hospital, Japan.

出版信息

Acta Otolaryngol Suppl. 1993;501:100-2. doi: 10.3109/00016489309126226.

DOI:10.3109/00016489309126226

PMID:7680518

Abstract

Xian-Qing-Long-Tang (XQLT), a Chinese medicine, is useful for treating allergic diseases. To demonstrate the anti-allergic effect of this drug we examined its effect on degranulation and histamine release from rat mast cells induced by antigen and compound 48/80. The effect on 48 h homologous passive cutaneous anaphylaxis (PCA) in rats was also studied. In the IgE antigen-antibody reaction using DNP-As, XQLT inhibited histamine release from rat mast cells, in vitro; it also inhibited 48 h rat homologous PCA reaction, in vivo. These results suggest that XQLT inhibits type 1 allergic reaction, and has effectiveness for allergic disease.

摘要

仙灵青龙汤（XQLT）是一种中药，对治疗过敏性疾病有效。为证明该药物的抗过敏作用，我们检测了其对抗原和化合物48/80诱导的大鼠肥大细胞脱颗粒和组胺释放的影响。还研究了其对大鼠48小时同种被动皮肤过敏反应（PCA）的影响。在使用二硝基苯砷酸盐（DNP-As）的IgE抗原-抗体反应中，仙灵青龙汤在体外抑制大鼠肥大细胞组胺释放；在体内也抑制大鼠48小时同种PCA反应。这些结果表明，仙灵青龙汤抑制I型过敏反应，对过敏性疾病有效。