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Effects of the Chinese herbal medicine "saiboku-to" on histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80.

作者信息

Toda S, Kimura M, Ohnishi M, Nakashima K

机构信息

Department of Pharmaceutical Science, Kansai Shinkyu Medical College, Osaka, Japan.

出版信息

J Ethnopharmacol. 1988 Dec;24(2-3):303-9. doi: 10.1016/0378-8741(88)90159-6.

DOI:10.1016/0378-8741(88)90159-6
PMID:2473358
Abstract

The herbal medicine "Saiboku-to" (ST) has been used for the treatment of bronchial asthma. ST was found to inhibit histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80. Its inhibitory effects were concentration-related and somewhat weaker than disodium cromoglycate, a known inhibitor of histamine release and mast cell degranulation. From these results, ST could appear to be useful in the treatment of Type I allergic reactions.

摘要

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Clin Rev Allergy Immunol. 1996 Fall;14(3):321-36. doi: 10.1007/BF02802221.