Amores A E, Sprekelsen C, Bernal-Sprekelsen M
ENT Department, University of Murcia, Spain.
Eur Arch Otorhinolaryngol. 1991;248(8):487-91. doi: 10.1007/BF00627640.
The presence of immunoreactive nervous fibers in the respiratory nasal mucosa of rats and guinea pigs was studied by means of a modified peroxidase antiperoxidase technique for whole mounting. The fibers with neuropeptide Y (NPY) always appeared in the walls of blood vessels, while the fibers immunoreactive to calcitonin gene-related peptide (CGRP) were found in nerve tracts near the vessels and the acini of seromucous glands as thick networks located in the subepithelial layers. Immunoreactivity (IR) for galanin was found in the mucosa studied. The findings after surgical and chemical denervation of the trigeminal and superior cervical ganglia may support the theory that the fibers with NPY are of a sympathetic nature with the superior cervical ganglion their site of origin, while the CGRP-IR fibers may have a sensory nature.
采用改良的过氧化物酶抗过氧化物酶全组织包埋技术，研究了大鼠和豚鼠呼吸道鼻黏膜中免疫反应性神经纤维的存在情况。含神经肽Y（NPY）的纤维总是出现在血管壁中，而对降钙素基因相关肽（CGRP）呈免疫反应的纤维则见于血管附近的神经束以及浆液黏液性腺泡中，呈位于上皮下层的粗大网络状。在所研究的黏膜中发现了甘丙肽的免疫反应性（IR）。三叉神经节和颈上神经节手术及化学去神经支配后的结果可能支持这样一种理论，即含NPY的纤维具有交感神经性质，其起源部位是颈上神经节，而CGRP免疫反应性纤维可能具有感觉神经性质。
