Martis Gianni, Diana Massimo, Ombres Maurizio, Cardi Antonio, Mastrangeli Roberta, Mastrangeli Bruno
Department of Urology, S. Camillo Hospital, Rieti, Italy.
J Surg Oncol. 2007 May 1;95(6):513-8. doi: 10.1002/jso.20714.
Prostate cancer is the most common malignancy in men and the second leading cause of cancer death. A randomized study was performed on patients with localized prostate cancer and treated with radical prostatectomy using the perineal or the retropubic approach comparing oncological outcomes, cancer control, and functional results.
Between 1997 and 2004, in a randomized study 200 patients underwent a radical prostatectomy performed by retropubic (100 patients) or perineal (100 patients) approach.
Differences between hospital stay, duration of catheter drainage, intraoperative blood loss, and transfusion requirements were statistically significant in favor of perineal prostatectomy. Differences between positive surgical margins and urinary continence in the two groups were not statistically significant at 6 and 24 months. Differences between erectile function at 24 months were statistically significant in favor of retropubic prostatectomy.
Radical perineal prostatectomy is an excellent alternative approach for radical surgery in the treatment of early prostate cancer.
前列腺癌是男性最常见的恶性肿瘤，也是癌症死亡的第二大主要原因。对局限性前列腺癌患者进行了一项随机研究，这些患者接受了经会阴或耻骨后途径的根治性前列腺切除术，比较了肿瘤学结果、癌症控制和功能结果。
1997年至2004年期间，在一项随机研究中，200例患者接受了经耻骨后（100例患者）或经会阴（100例患者）途径的根治性前列腺切除术。
住院时间、导尿管引流时间、术中失血量和输血需求方面的差异在统计学上有显著意义，有利于经会阴前列腺切除术。两组在6个月和24个月时手术切缘阳性率和尿失禁情况的差异无统计学意义。24个月时勃起功能的差异在统计学上有显著意义，有利于耻骨后前列腺切除术。
根治性经会阴前列腺切除术是早期前列腺癌根治性手术的一种优秀替代方法。
