Lim Mi Hee, Lippard Stephen J
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Acc Chem Res. 2007 Jan;40(1):41-51. doi: 10.1021/ar950149t.
Nitric oxide, a reactive free radical, regulates a variety of biological processes. The absence of tools to detect NO directly, rapidly, specifically, and selectively motivated us to synthesize metal-based fluorescent probes to visualize the presence of NO. We prepared and investigated Co(II), Fe(II), Ru(II), Rh(II), and Cu(II) complexes as turn-on fluorescent NO sensors. Our exploration has provided insight into how the interaction of transition-metal centers with nitric oxide can be utilized for NO sensing.
一氧化氮是一种活性自由基，可调节多种生物过程。由于缺乏直接、快速、特异且选择性地检测一氧化氮的工具，促使我们合成基于金属的荧光探针以可视化一氧化氮的存在。我们制备并研究了钴（II）、铁（II）、钌（II）、铑（II）和铜（II）配合物作为开启型荧光一氧化氮传感器。我们的探索为如何利用过渡金属中心与一氧化氮的相互作用进行一氧化氮传感提供了见解。
