Caruso R A
Dipartimento di Patologia Umana, University of Messina, Italy.
Eur J Basic Appl Histochem. 1991;35(2):203-9.
A case of gastric adenocarcinoma with patterns resembling those of hepatocellular carcinoma is reported. The hepatoid component of the tumour was characterized by discrete masses, nests and broad bands of large polyhedral cells with central nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm; single-nucleus giant cells were frequently noted. Varying numbers of tumour cells stained immunohistochemically for alpha-fetoprotein (AFP), alpha-1-antitrypsin (AAT), and albumin. Thus, in this hepatoid gastric adenocarcinoma tumour cells demonstrated both morphologic and immunohistochemical features of partial differentiation in hepatocellular carcinoma. Careful histological examination in conjunction with the immunohistochemical demonstration of AFP and other serum proteins can provide an useful contribution to the diagnosis of this rare histological type of gastric carcinoma.
本文报告一例胃腺癌，其形态类似于肝细胞癌。肿瘤的肝样成分表现为离散的肿块、巢状结构和由大的多面体细胞构成的宽带状结构，这些细胞具有中央核、明显的核仁以及丰富的嗜酸性细胞质；常可见单核巨细胞。不同数量的肿瘤细胞免疫组化染色显示甲胎蛋白（AFP）、α-1抗胰蛋白酶（AAT）和白蛋白呈阳性。因此，在这种肝样胃腺癌中，肿瘤细胞表现出肝细胞癌部分分化的形态学和免疫组化特征。结合AFP及其他血清蛋白的免疫组化检测进行仔细的组织学检查，有助于诊断这种罕见组织学类型的胃癌。
