Antonini C, Forgiarini O, Chiara A, Briani G, Sacchi G
Servizio di Anatomia e Istologia patologica, ULSS 10 Veneto Orientale Ospedale di S. Donà di Piave, Venezia.
Pathologica. 1997 Jun;89(3):310-6.
Hepatoid adenocarcinoma of the stomach is an uncommon gastric tumor. A throughout search of the literature revealed only 86 cases: the first case was reported by Bourreille et al in 1970. We describe a patient with primary gastric adenocarcinoma with high serum alpha-fetoprotein (AFP) levels (7000 ng/ml). Histologically foci strongly resembling hepatocellular carcinoma with hyaline globules were noted. Immunoreactivity for alpha-fetoprotein (AFP), a1 antitrypsin and CEA also indicate hepatocellular differentiation. This case provides informations on the DNA content and Ki67 expression of this unusual and aggressive variant of gastric adenocarcinoma.
