Song H, Li S, Yang Y
304th Hospital, PLA, Beijing.
Zhonghua Zhong Liu Za Zhi. 1995 Jan;17(1):56-9.
Routine examination of pathologic sections in 500 cases of primary gastric adenocarcinomas was carried out by light microscopy. Regions of hepatocellular carcinomatoid differentiation were discovered in 12 of the 500 cases. In 11 of them, histopathologic features were described in great detail and the hepatocellular carcinomatoid regions were studied by four kinds of immunohistochemistrical methods. The results indicate that positive staining for AFP was seen in 9 cases but negative in 9 controls, weakly positive for CEA in 10 cases, but strongly positive in 8 controls. Staining for alpha 1-AT and alpha 1-ACT showed no differences as compared to controls. The clinical pathological features and its relationship with AFP are discussed. It is suggested that hepatoid gastric adenocarcinoma is a subtype of gastric adenocarcinoma.
对500例原发性胃腺癌的病理切片进行了常规光学显微镜检查。在500例病例中，有12例发现了肝细胞样癌分化区域。其中11例详细描述了组织病理学特征，并采用四种免疫组织化学方法对肝细胞样癌区域进行了研究。结果显示，9例甲胎蛋白（AFP）染色呈阳性，而9例对照呈阴性；10例癌胚抗原（CEA）弱阳性，8例对照呈强阳性。α1-抗胰蛋白酶（α1-AT）和α1-抗糜蛋白酶（α1-ACT）染色与对照相比无差异。讨论了临床病理特征及其与AFP的关系。提示肝样胃腺癌是胃腺癌的一种亚型。
