Buchman Joshua J, Tsai Li-Huei
Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.
Nat Rev Neurosci. 2007 Feb;8(2):89-100. doi: 10.1038/nrn2058. Epub 2007 Jan 17.
The mitotic spindle is the cellular scaffold that facilitates proper segregation of genetic material during cell division. Far from being static, the spindle is a dynamically regulated tool that can alter its size, shape and position during mitosis. Work in both insect and vertebrate systems has shown that regulation of this structure involves an array of highly conserved proteins. Moreover, it is now clear that tight regulation of the spindle during the process of neurogenesis is paramount to proper cell division and generation of the nervous system as a whole.
有丝分裂纺锤体是一种细胞支架，可在细胞分裂过程中促进遗传物质的正确分离。纺锤体远非静止不动，而是一种动态调节的工具，在有丝分裂过程中可改变其大小、形状和位置。在昆虫和脊椎动物系统中的研究均表明，对这种结构的调节涉及一系列高度保守的蛋白质。此外，现在很清楚的是，在神经发生过程中对纺锤体进行严格调节对于正确的细胞分裂以及整个神经系统的生成至关重要。
