Goriely S, Goldman M
Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium.
Am J Transplant. 2007 Feb;7(2):278-84. doi: 10.1111/j.1600-6143.2006.01651.x. Epub 2007 Jan 4.
Since several years ago, interleukin (IL)-12 is known to be responsible for the differentiation of naive CD4+ T cells into type 1 helper T cells producing interferon-gamma. Recently, two other cytokines of the IL-12 family, IL-23 and IL-27, were shown to play key roles in experimental autoimmune disorders mediated by Th17 cells, a novel pro-inflammatory CD4+ T-cell subset secreting IL-17. As our knowledge of IL-12 family members is rapidly growing and changing, it will be important to specify their involvement in the induction and regulation of allograft rejection in animal models as well as in clinical settings. Herein, we review key features of cytokines belonging to the IL-12 family and discuss their potential relevance to transplantation immunity.
数年前起，白细胞介素（IL）-12就被认为在将初始CD4+ T细胞分化为产生γ干扰素的1型辅助性T细胞过程中发挥作用。最近，IL-12家族的另外两种细胞因子，IL-23和IL-27，被证明在由Th17细胞介导的实验性自身免疫性疾病中起关键作用，Th17细胞是一种分泌IL-17的新型促炎性CD4+ T细胞亚群。随着我们对IL-12家族成员的了解迅速增加和不断变化，明确它们在动物模型以及临床环境中同种异体移植排斥反应的诱导和调节中的作用将很重要。在此，我们综述了IL-12家族细胞因子的关键特征，并讨论了它们与移植免疫的潜在相关性。
