Stratiki Z, Costalos C, Sevastiadou S, Kastanidou O, Skouroliakou M, Giakoumatou A, Petrohilou V
Department of Neonatal Medicine, Alexandra Regional General Hospital, Athens, Greece.
Early Hum Dev. 2007 Sep;83(9):575-9. doi: 10.1016/j.earlhumdev.2006.12.002. Epub 2007 Jan 16.
Preterm infants have increased intestinal permeability which can render them susceptible to infections from enterobacteriae.
The primary objective was to investigate whether probiotic administration to preterm infants decreases intestinal permeability. Secondary outcomes studied were: somatic growth, tolerance, rates of sepsis and necrotizing enterocolitis.
In a prospective randomized case-control study 41 stable preterm infants of 27 to 36 weeks gestation and 34 matched comparison infants consecutively admitted to the neonatal unit were studied. The study group received a preterm formula supplemented with Bifidobacter lactis (2 x 10(7) cfu/g of dry milk) while the control group received the same formula but without supplementation. Intestinal permeability was measured within two days of birth and then seven and thirty days later using the sugar absorption test. Additionally anthropometric parameters were recorded throughout the study as well as acceptance and tolerance of the formula.
All infants tolerated the study formula well. Median counts of stool bifidobacteria and lactulose/mannitol ratios at baseline were comparable. After 7 days of supplementation median bifidobacteria counts were significantly higher in the study group than in the control group (p=0.0356) and they remained higher to the end of the study (p at day 30=0.075). The L/M ratio in the study group was significantly lower at day 30 of the study as compared to the control group (p=0.003). Head growth was significantly higher in the study group (p=0.001).
The administration of a bifidobacter supplemented infant formula decreases intestinal permeability of preterm infants and leads to increased head growth.
早产儿肠道通透性增加，这使他们易受肠杆菌感染。
主要目的是研究对早产儿施用益生菌是否会降低肠道通透性。研究的次要结果包括：体格生长、耐受性、败血症和坏死性小肠结肠炎的发生率。
在一项前瞻性随机病例对照研究中，对41名孕周为27至36周的稳定早产儿和34名连续入住新生儿病房的匹配对照婴儿进行了研究。研究组接受添加了乳酸双歧杆菌（2×10⁷ cfu/g干奶粉）的早产儿配方奶粉，而对照组接受相同的配方奶粉但未添加。在出生后两天内以及随后的第七天和第三十天使用糖吸收试验测量肠道通透性。此外，在整个研究过程中记录人体测量参数以及配方奶粉的接受度和耐受性。
所有婴儿对研究配方奶粉耐受性良好。基线时粪便双歧杆菌计数中位数和乳果糖/甘露醇比率具有可比性。补充7天后，研究组的双歧杆菌计数中位数显著高于对照组（p = 0.0356），并且在研究结束时仍然较高（第30天时p = 0.075）。在研究的第30天，研究组的L/M比率显著低于对照组（p = 0.003）。研究组的头围生长显著更高（p = 0.001）。
施用添加双歧杆菌的婴儿配方奶粉可降低早产儿的肠道通透性并导致头围生长增加。
