Mensah George A, Ryan Una S, Hooper W Craig, Engelgau Michael M, Callow Allan D, Kapuku Gaston K, Mantovani Alberto
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, (CDC), Mailstop K-40, 4770 Buford Highway NE, Atlanta, GA 30341-3717, USA.
Vascul Pharmacol. 2007 May;46(5):318-20. doi: 10.1016/j.vph.2006.10.019. Epub 2006 Nov 21.
The prevention and control of cardiovascular disease (CVD), principally ischemic heart disease and stroke, are a major clinical and public health challenge. Worldwide, CVD accounts for substantial morbidity and mortality. The major modifiable CVD risk factors are known and all of them cause endothelial activation and dysfunction. Preventing and controlling the established risk factors are associated with preserved endothelial function and reduced risk of CVD. Research advances that improve our understanding of strategies to preserve endothelial function or make the endothelial cells resilient to environmental insults may help improve our preventive interventions. This summary statement addresses the current state of the science with respect to endothelial dysfunction and CVD pathogenesis, diagnostic evaluation, and suggested strategies for public health practice and research.
心血管疾病（CVD）的预防和控制，主要是缺血性心脏病和中风，是一项重大的临床和公共卫生挑战。在全球范围内，心血管疾病导致了大量的发病和死亡。主要的可改变的心血管疾病风险因素是已知的，并且所有这些因素都会导致内皮激活和功能障碍。预防和控制已确定的风险因素与维持内皮功能和降低心血管疾病风险相关。增进我们对维持内皮功能策略或使内皮细胞对环境损伤具有恢复力的策略的理解的研究进展，可能有助于改善我们的预防性干预措施。本总结声明阐述了关于内皮功能障碍与心血管疾病发病机制、诊断评估以及公共卫生实践和研究建议策略的科学现状。
