Goldner-Sauvé A, Szpirer C, Szpirer J, Levan G, Gasser D L
Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104.
Biochem Genet. 1991 Jun;29(5-6):275-86. doi: 10.1007/BF00590108.
We have utilized rat-mouse somatic cell hybrids to make chromosomal assignments for the glucocorticoid receptor (GR), myelin basic protein (MBP), leukocyte common antigen (LCA), and testosterone-repressed prostate message-2 (TRPM2) genes in the rat. The genes for GR and MBP both map on chromosome 18 of the rat, which corresponds to the mapping of both genes on chromosome 18 of the mouse. The gene for LCA maps on chromosome 13, which is where C4b-binding protein beta-chain (C4BPB), coagulation factor V (F5), and renin have previously been assigned. This linkage group appears to be homologous to a substantial portion of mouse chromosome 1 and human chromosome 1q. Finally, the TRPM2 gene has been assigned to rat chromosome 15.
我们利用大鼠-小鼠体细胞杂种对大鼠体内的糖皮质激素受体（GR）、髓鞘碱性蛋白（MBP）、白细胞共同抗原（LCA）和睾酮抑制的前列腺信息-2（TRPM2）基因进行染色体定位。GR和MBP基因均定位于大鼠的18号染色体，这与它们在小鼠18号染色体上的定位相对应。LCA基因定位于13号染色体，此前C4b结合蛋白β链（C4BPB）、凝血因子V（F5）和肾素也被定位于此。该连锁群似乎与小鼠1号染色体和人类1q染色体的很大一部分同源。最后，TRPM2基因已被定位于大鼠15号染色体。
