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在大鼠中，编码生长激素和催乳素的相关基因已分散到第10号和第17号染色体上。

The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat.

作者信息

Cooke N E, Szpirer C, Levan G

出版信息

Endocrinology. 1986 Dec;119(6):2451-4. doi: 10.1210/endo-119-6-2451.

DOI:10.1210/endo-119-6-2451
PMID:3780533
Abstract

We have assigned the rat GH gene to chromosome 10 and the rat PRL gene to chromosome 17. DNA from a series of mouse BWTG3 x rat hepatocyte somatic cell hybrids, each of which has retained a unique complement of rat chromosomes, was analyzed for the presence of rat GH and PRL genomic fragments by Southern blotting. Radiolabeled complementary DNAs (cDNAs) encoding rat GH and rat PRL were used as molecular probes. Based upon these assignments, we conclude that the evolutionarily related GH and PRL genes have been dispersed to different chromosomes in rat as in man.

摘要

我们已将大鼠生长激素（GH）基因定位到第10号染色体，将大鼠催乳素（PRL）基因定位到第17号染色体。通过Southern印迹分析了一系列小鼠BWTG3×大鼠肝细胞体细胞杂种的DNA，每个杂种都保留了独特的大鼠染色体互补片段，以检测大鼠GH和PRL基因组片段的存在。编码大鼠GH和大鼠PRL的放射性标记互补DNA（cDNA）用作分子探针。基于这些定位，我们得出结论，与人类一样，在大鼠中，进化上相关的GH和PRL基因已分散到不同的染色体上。

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Endocrinology. 1986 Dec;119(6):2451-4. doi: 10.1210/endo-119-6-2451.
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