Ajduković Zorica, Ignjatović Nenad, Petrović Dragan, Uskoković Dragan
Faculty of Medicine, Nis, Clinic of Stomatology, Department of Prosthodontics, Nis, Serbia and Montenegro.
J Biomater Appl. 2007 Jan;21(3):317-28. doi: 10.1177/0885328207073760.
Lost bone tissue due to osteoporosis makes dentistry very difficult. The aim of thisstudy is to reconstruct the bone tissue with composite biomaterials and to estimate the optical density and alveolar ridge height of the mandible. Research is conducted on 30 postmenopausal women aged from 46 to 62 years, with diagnosed osteoporosis and defects in alveolar bones caused by extraction of paradontopathic teeth, enucleation of cysts and periapical changes, extraction of impacted teeth,or by trauma.Biphasic calcium phosphate/poly-DL-lactide-co-glycolide (BCP/PLGA) composite is implanted into the defects of alveolar bones. Six weeks after implantation of BCP/PLGA, the alveolar bone density in the region of premolars on the experimental side of the jaw is found to be lower than that on the untreated, control, side of the jaw. On thecontrary, 24 weeks after implantation, it is significantly higher compared with the density of the control side. A significant increase in optical density of alveolar bones in the region of premolars on the experimental side compared with the control one is noticed. These results indicate a high level of osteoregeneration and osteoblast activity. Synthetic BCP/PLGA composite belongs to the group of biomaterials, which facilitate formation of new bones and rehabilitation of alveolar bones weakened by osteoporosis. Because of its osteoconductive characteristics, BCP/PLGA composite is supposed to be the material of choice for replacement of bone tissue in the future.
骨质疏松导致的骨组织流失使牙科治疗变得非常困难。本研究的目的是用复合生物材料重建骨组织，并评估下颌骨的光密度和牙槽嵴高度。对30名年龄在46至62岁之间的绝经后女性进行了研究，她们被诊断患有骨质疏松症，且因牙周病牙齿拔除、囊肿摘除和根尖周病变、阻生牙拔除或外伤导致牙槽骨缺损。将双相磷酸钙/聚-DL-丙交酯-共-乙交酯（BCP/PLGA）复合材料植入牙槽骨缺损处。植入BCP/PLGA六周后，发现颌骨实验侧前磨牙区域的牙槽骨密度低于未处理的对照侧。相反，植入24周后，与对照侧密度相比显著更高。与对照侧相比，实验侧前磨牙区域的牙槽骨光密度显著增加。这些结果表明骨再生和成骨细胞活性水平较高。合成的BCP/PLGA复合材料属于促进新骨形成和修复因骨质疏松而减弱的牙槽骨的生物材料组。由于其骨传导特性，BCP/PLGA复合材料有望成为未来替代骨组织的首选材料。
