Jensen Kristin C, Kong Christina S
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5324, USA.
Diagn Cytopathol. 2007 Feb;35(2):73-9. doi: 10.1002/dc.20601.
This study describes the cytologic features of breast columnar-cell lesions (CCLs) and determines whether these lesions can be diagnosed by fine-needle aspiration. We present ten cases of biopsy-proven CCL with prior fine-needle aspiration material and discuss the spectrum of changes, as well as features important in the cytologic distinction of CCL from diagnostic mimics. CCLs were characterized by flat sheets of cells with enlarged nuclei, distinct cell borders, and finely granular cytoplasm. Cytologic atypia ranged from minimal to severe, and many cases (8/10) exhibited a paucity of myoepithelial cells. CCL showed significant cytologic overlap with papillary neoplasms and well-differentiated adenocarcinomas. The prospective diagnosis of CCL cannot reliably be made by fine-needle aspiration. However, it is important to recognize the range of cytologic atypia that can be seen with CCL to avoid an overdiagnosis of malignancy.
本研究描述了乳腺柱状细胞病变（CCLs）的细胞学特征，并确定这些病变能否通过细针穿刺进行诊断。我们展示了10例经活检证实的CCL病例，其之前有细针穿刺取材，并讨论了变化范围，以及在CCL与诊断性模仿病变的细胞学鉴别中重要的特征。CCLs的特征是细胞呈扁平片状，细胞核增大，细胞边界清晰，细胞质呈细颗粒状。细胞学异型性从轻微到严重不等，许多病例（8/10）显示肌上皮细胞稀少。CCL与乳头状肿瘤和高分化腺癌在细胞学上有显著重叠。通过细针穿刺不能可靠地对CCL进行前瞻性诊断。然而，认识到CCL可能出现的细胞学异型性范围很重要，以避免过度诊断为恶性肿瘤。
