Schmauz R, Hoppe W, zur Hausen H
Dtsch Med Wochenschr. 1975 Dec 5;100(49):2527-9. doi: 10.1055/s-0028-1106579.
Clinical and histological examination of a cervical lymph node, removed from a 15-year-old boy, revealed nasopharyngeal carcinoma as the probable diagnosis. But the decisive diagnostic pointer was a markedly raised Epstein-Barr virus antibody titre, which gives the diagnosis at a time when there may not as yet be clinical evidence of carcinoma. Serial serum titre determinations are of prognostic value: with increasing spread of the tumour there is a rise in antibody titre. Autopsy confirmed that the nasopharynx had been the site of the primary tumour.
对一名15岁男孩切除的颈部淋巴结进行临床和组织学检查,结果显示可能诊断为鼻咽癌。但决定性的诊断依据是爱泼斯坦-巴尔病毒抗体滴度显著升高,这在癌肿可能尚无临床证据之时即可做出诊断。连续进行血清滴度测定具有预后价值:随着肿瘤扩散加剧,抗体滴度会升高。尸检证实鼻咽部是原发肿瘤的部位。