Yamaguchi M, Koike K, Matsuzaki N, Yoshimoto Y, Taniguchi T, Miyake A, Tanizawa O
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
J Endocrinol Invest. 1991 Jun;14(6):457-61. doi: 10.1007/BF03346841.
The effects of interferon-alpha, interferon-beta 1 and interferon-gamma on the secretions of prolactin (PRL) and interleukin-6 by primary cultured rat anterior pituitary cells were examined. These three interferons caused dose-dependent increases in PRL secretion within 30 min, and dose-dependent stimulation of interleukin-6 were weaker than the effects of interleukin-1 and tumor necrosis factor-alpha. These results suggest that interferons regulate PRL secretion from the pituitary gland, and that there may be a pathway in which interferons stimulate PRL secretion through interleukin-6 release.
研究了α干扰素、β-1干扰素和γ干扰素对原代培养的大鼠垂体前叶细胞催乳素（PRL）分泌及白细胞介素-6分泌的影响。这三种干扰素在30分钟内使PRL分泌呈剂量依赖性增加，而对白细胞介素-6的剂量依赖性刺激作用弱于白细胞介素-1和肿瘤坏死因子-α。这些结果表明，干扰素调节垂体的PRL分泌，并且可能存在一条干扰素通过白细胞介素-6释放来刺激PRL分泌的途径。
