苦树（Picralima nitida）乙醇种子提取物的抗疟活性评估。

Evaluation of antiplasmodial activity of ethanolic seed extract of Picralima nitida.

作者信息

Okokon Jude E, Antia B S, Igboasoiyi A C, Essien E E, Mbagwu H O C

机构信息

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.

出版信息

J Ethnopharmacol. 2007 May 22;111(3):464-7. doi: 10.1016/j.jep.2006.12.016. Epub 2006 Dec 20.

DOI:10.1016/j.jep.2006.12.016

PMID:17234375

Abstract

The in vivo antiplasmodial activity of the ethanol seed extract of Picralima nitida grown particularly for the leaf and seed in Niger Delta region of Nigeria was evaluated in Plasmodium berghei berghei infected mice. Picralima nitida (35-115 mg/kg day) exhibited significant (P<0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time though not comparable to that of the standard drug, chloroquine, 5 mg/kg day. The seed extract possesses significant (P<0.05) antiplasmodial activity which correlate with it reported in vitro activity.

摘要

对在尼日利亚尼日尔三角洲地区专门种植以获取叶子和种子的光亮海木乙醇种子提取物，在感染伯氏疟原虫的小鼠体内进行了抗疟活性评估。光亮海木（35 - 115毫克/千克/天）在4天早期感染试验和已建立感染的情况下均表现出显著（P<0.05）的血液裂殖体杀灭活性，平均存活时间可观，尽管与标准药物氯喹（5毫克/千克/天）不可比。种子提取物具有显著（P<0.05）的抗疟活性，这与其体外活性报道相关。