Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), P.M.B 21 Garki, Abuja, Nigeria.
Pharm Biol. 2012 Feb;50(2):188-94. doi: 10.3109/13880209.2011.592537.
Bridelia ferruginea Benth (Euphorbiaceae) is an indigenous medicinal plant in Nigeria. It is usually a gnarled shrub which sometimes reaches the size of a tree in suitable condition. Decoctions of parts of this plant have been employed in ethno medicine in many parts of Africa for treatment of many ailments including malaria fever.
In vivo antiplasmodial activity of aqueous stem bark extract of BF was investigated against Plasmodium berghei-infected mice.
The aqueous stem bark extract of BF (100-400 mg/kg) was administered orally to P. berghei-infected mice in both early and established models of antiplasmodial studies.
The extract exhibited significant (p < 0.05) antiplasmodial activity in early and established infection tests with a considerable mean survival time comparable to that of chloroquine, 10 mg/kg. The oral LD(50) obtained was greater than 5000 mg/kg in mice.
The findings show that aqueous stem bark extract of Bridelia ferruginea possesses considerable antiplasmodial activity which can be developed in malaria therapy.
Bridelia ferruginea Benth（大戟科）是尼日利亚本土药用植物。它通常是一种多节的灌木，在适宜的条件下有时会长成树的大小。该植物的部分提取物在非洲许多地方的民族医学中被用于治疗多种疾病，包括疟疾发热。
研究 BF 的水提茎皮提取物对感染伯氏疟原虫的小鼠的体内抗疟原虫活性。
BF 的水提茎皮提取物（100-400mg/kg）以口服方式给予在早期和抗疟原虫研究的已建立模型中感染伯氏疟原虫的小鼠。
该提取物在早期和已建立的感染测试中表现出显著的（p<0.05）抗疟原虫活性，其平均存活时间与 10mg/kg 的氯喹相当。在小鼠中获得的口服 LD50 大于 5000mg/kg。
这些发现表明，Bridelia ferruginea 的水提茎皮提取物具有相当的抗疟原虫活性，可用于疟疾治疗。
