Okokon Jude E, Ita Basil N, Udokpoh Aniekan E
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
J Ethnopharmacol. 2006 Sep 19;107(2):175-8. doi: 10.1016/j.jep.2006.03.002. Epub 2006 Mar 17.
The antimalarial activity of ethanolic stembark extract of Cylicodiscus gabunensis was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections as well as for repository activity. The LD(50) of the extract was determined to be 223.6 mg/kg, while doses of 250 mg/kg and above were found to be lethal to mice. Cylicodiscus gabunensis extract (20-60 mg/kg/day) exhibited a significant (P<0.05) blood schizontocidal activity in 4-day early infection, repository evaluation and in established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The stembark extract possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
在早期感染和已确诊感染期间，对感染了伯氏疟原虫的小鼠体内加蓬旋柱麻乙醇茎皮提取物的抗疟活性进行了研究，并对其储存活性进行了研究。提取物的半数致死量（LD50）测定为223.6毫克/千克，而250毫克/千克及以上的剂量对小鼠具有致死性。加蓬旋柱麻提取物（20 - 60毫克/千克/天）在4天的早期感染、储存评估和已确诊感染中表现出显著（P<0.05）的血内裂殖体杀灭活性，其平均生存时间与标准药物氯喹（5毫克/千克/天）相当。茎皮提取物具有有前景的抗疟活性，可用于疟疾治疗。
