脓肿中巨噬细胞样细胞对免疫反应性白细胞弹性蛋白酶抑制剂复合物的摄取。
Uptake of immunoreactive leukocyte elastase-inhibitor complexes in macrophage-like cells in abscesses.
作者信息
Delshammar M, Lasson A, Ohlsson K
机构信息
Department of Surgery, University of Lund, Malmö General Hospital, Sweden.
出版信息
Eur Surg Res. 1991;23(3-4):256-60. doi: 10.1159/000129161.
Leukocyte elastase was demonstrated immunohistochemically not only in PMN-leukocytes in subcutaneous abscesses but also in scattered macrophage-like cells which in addition contained immunoreactive alpha 1-proteinase inhibitor (alpha 1PI) and alpha 2-macroglobulin (alpha 2M). These cells were located mainly in the marginal region of the abscess. It is concluded that the intracellular deposits in the macrophage-like cells represent phagocytized elastase and/or elastase-alpha 1PI and elastase-alpha 2M complexes. A contributing, local production of the inhibitor is, however, not excluded by the present findings.
免疫组织化学显示，白细胞弹性蛋白酶不仅存在于皮下脓肿中的中性粒细胞中，还存在于散在的巨噬细胞样细胞中，这些细胞还含有免疫反应性α1-蛋白酶抑制剂（α1PI）和α2-巨球蛋白（α2M）。这些细胞主要位于脓肿的边缘区域。可以得出结论，巨噬细胞样细胞中的细胞内沉积物代表吞噬的弹性蛋白酶和/或弹性蛋白酶-α1PI以及弹性蛋白酶-α2M复合物。然而，目前的研究结果并不排除抑制剂存在局部产生的情况。
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