高压氧用于儿童和青少年慢性复发性下颌骨骨髓炎的辅助治疗
Hyperbaric oxygen for adjuvant therapy for chronically recurrent mandibular osteomyelitis in childhood and adolescence.
作者信息
Lentrodt Stefan, Lentrodt Jürgen, Kübler Norbert, Mödder Ulrich
机构信息
Hyperbaric Oxygen Unit, Institute of Diagnostic Radiology, Institute of Diagnostic Radiology and the Clinic of Maxillofacial Plastic Surgery, Westdeutsche Kieferklinik, University Hospital Düsseldorf, Düsseldorf, Germany.
出版信息
J Oral Maxillofac Surg. 2007 Feb;65(2):186-91. doi: 10.1016/j.joms.2005.11.106.
PURPOSE
In this article, the question of whether adjuvant hyperbaric oxygen therapy (HBO) has a positive effect when treating chronically recurrent mandibular osteomyelitis in children and adolescents is discussed.
PATIENTS AND METHODS
Over a period of 5 years, 4 cases were observed, 3 of which were submitted to adjuvant HBO. Details on the modalities of this type of treatment and the simultaneous intravenous administration of high doses of antibiotics are reported.
RESULTS
All 3 patients have been free of any symptoms from 20 to 74 months (mean, 41 months) and therefore may most likely be regarded as healed.
CONCLUSION
The small number of cases does not allow a final statement on the extent to which HBO contributed to the positive outcome. However, in our opinion, HBO is a most promising therapeutic option. Finally, the problems involved in prospective randomized studies of this rare disease are discussed in detail.
目的
本文讨论辅助高压氧疗法（HBO）在治疗儿童和青少年慢性复发性下颌骨骨髓炎时是否具有积极作用这一问题。
患者与方法
在5年的时间里，观察了4例患者，其中3例接受了辅助HBO治疗。报告了此类治疗方式以及同时静脉注射高剂量抗生素的详细情况。
结果
所有3例患者在20至74个月（平均41个月）内均无任何症状，因此很可能被视为已治愈。
结论
病例数量较少，无法就HBO对积极治疗结果的贡献程度作出最终定论。然而，我们认为，HBO是一种非常有前景的治疗选择。最后，详细讨论了对这种罕见疾病进行前瞻性随机研究时所涉及的问题。
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