Gold Douglas G, Miller Robert C, Petersen Ivy A, Osborn Thomas G
Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):559-67. doi: 10.1016/j.ijrobp.2006.09.003.
To determine the frequency of acute and chronic adverse effects in patients with scleroderma who receive radiotherapy for treatment of cancer.
Records were reviewed of 20 patients with scleroderma who received radiotherapy. Acute and chronic toxic effects attributable to radiotherapy were analyzed, and freedom from radiation-related toxicity was calculated.
Of the 20 patients, 15 had acute toxic effects, with Grade 3 or higher toxicity for 3 patients. Seven patients had self-limited Grade 1 or 2 radiation dermatitis, and no patient had Grade 3 or higher radiation dermatitis. Thirteen patients had chronic toxic effects, with Grade 3 or higher chronic toxicity for 3 patients. The median estimated time to any grade chronic toxicity was 0.4 years, and the median estimated time to Grade 3 or higher chronic toxicity has not been reached.
The results suggest that although some patients with scleroderma treated with radiation experience considerable toxic effects, the occurrence of Grade 3 or higher toxicity may be less than previously anticipated.
确定接受放射治疗以治疗癌症的硬皮病患者中急性和慢性不良反应的发生率。
回顾了20例接受放射治疗的硬皮病患者的记录。分析了放射治疗引起的急性和慢性毒性作用，并计算了无辐射相关毒性的情况。
20例患者中，15例有急性毒性作用，3例为3级或更高等级毒性。7例患者有自限性1级或2级放射性皮炎，无患者有3级或更高等级放射性皮炎。13例患者有慢性毒性作用，3例为3级或更高等级慢性毒性。发生任何等级慢性毒性的估计中位时间为0.4年，未达到3级或更高等级慢性毒性的估计中位时间。
结果表明，虽然一些接受放疗的硬皮病患者会出现相当大的毒性作用，但3级或更高等级毒性的发生率可能低于先前预期。
