Szabo Gyongyi, Dolganiuc Angela, Dai Qun, Pruett Stephen B
University of Massachusetts Medical School, Worcester, MA 01605, USA.
J Immunol. 2007 Feb 1;178(3):1243-9. doi: 10.4049/jimmunol.178.3.1243.
Ethanol (EtOH) is the most widely abused substance in the United States, and it contributes to well-documented harmful (at high dosages) and beneficial (at low dosages) changes in inflammatory and immune responses. Lipid rafts have been implicated in the regulation and activation of several important receptor complexes in the immune system, including the TLR4 complex. Many questions remain about the precise mechanisms by which rafts regulate the assembly of these receptor complexes. Results summarized in this review indicate that EtOH acts by altering the LPS-induced redistribution of components of the TLR4 complex within the lipid raft and that this is related to changes in actin cytoskeleton rearrangement, receptor clustering, and subsequent signaling. EtOH provides an example of an immunomodulatory drug that acts at least in part by modifying lipid rafts, and it could represent a model to probe the relationships between rafts, receptor complexes, and signaling.
乙醇（EtOH）是美国滥用最为广泛的物质，它会导致炎症和免疫反应出现有充分记录的有害（高剂量时）和有益（低剂量时）变化。脂筏与免疫系统中几种重要受体复合物的调节和激活有关，包括Toll样受体4（TLR4）复合物。关于脂筏调节这些受体复合物组装的精确机制仍存在许多问题。本综述总结的结果表明，乙醇通过改变脂筏内TLR4复合物成分的脂多糖（LPS）诱导的重新分布起作用，这与肌动蛋白细胞骨架重排、受体聚集及随后的信号传导变化有关。乙醇提供了一种免疫调节药物的例子，该药物至少部分通过修饰脂筏起作用，它可能代表一个模型，用于探究脂筏、受体复合物和信号传导之间的关系。
