使用II型量子点进行前哨淋巴结定位
Sentinel lymph node mapping with type-II quantum dots.
作者信息
Frangioni John V, Kim Sang-Wook, Ohnishi Shunsuke, Kim Sungjee, Bawendi Moungi G
机构信息
Division of Hematology/Oncology, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
出版信息
Methods Mol Biol. 2007;374:147-59. doi: 10.1385/1-59745-369-2:147.
Abstract
Sentinel lymph node (SLN) mapping is an important cancer surgery during which the first lymph node draining the site of a tumor is identified, resected, and analyzed for the presence or absence of malignant cells. Fluorescent semiconductor nanocrystals (quantum dots [QDs]) of the appropriate size, charge, and emission wavelength permit this surgery to be performed rapidly, with high sensitivity and under complete image guidance. We describe the materials and methods necessary for the production and characterization of type-II near-infrared fluorescent QDs, which have been optimized for SLN mapping. They contain a CdTe core, CdSe shell, and a highly anionic, oligomeric phosphine organic coating. We also describe how to utilize such QDs in animal model systems of SLN mapping.
摘要
前哨淋巴结（SLN）定位是一项重要的癌症手术，在此过程中，确定、切除并分析引流肿瘤部位的首个淋巴结中是否存在恶性细胞。尺寸、电荷和发射波长合适的荧光半导体纳米晶体（量子点[QDs]）可使该手术快速进行，具有高灵敏度且在完全的图像引导下进行。我们描述了用于制备和表征II型近红外荧光量子点的材料和方法，这些量子点已针对SLN定位进行了优化。它们包含一个碲化镉核心、硒化镉壳层以及高度阴离子化的低聚膦有机涂层。我们还描述了如何在SLN定位的动物模型系统中利用此类量子点。
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