Símová J, Bubeník J
Folia Biol (Praha). 1975;21(5):329-33.
The effect of prophylactic and therapeutic administration of BCG vaccine on growth of transplantable sarcomas induced by MSV-Harvey (MSVT1) and 3-methylcholanthrene (MC 11 and MC 12) in C57BL/10Sn mice was studied. Growth of MSVT1 sarcomas was not inhibited by oral or intratumoral BCG therapy. Nor was prophylactic oral administration of BCG followed by therapeutic oral BCG treatment effective. On the other hand, intradermal administration of an adequate dose of BCG vaccine preceding the tumour transplantation inhibited tumour growth. The low (0.05-0.2 mg.) doses of BCG induced resistance comparable to the effect of subcutaneous immunization with tumour cells, whereas the higher (0.5-1.0 mg) doses had no effect. Growth of MC 11 and MC 12 tumours was not affected by prophylactic intradermal BCG administration.
研究了预防性和治疗性接种卡介苗对C57BL/10Sn小鼠中由哈维小鼠肉瘤病毒（MSV-Harvey，MSVT1）以及3-甲基胆蒽（MC 11和MC 12）诱导的可移植肉瘤生长的影响。口服或瘤内注射卡介苗治疗均未抑制MSVT1肉瘤的生长。预防性口服卡介苗后再进行治疗性口服卡介苗治疗也无效。另一方面，在肿瘤移植前皮内注射适当剂量的卡介苗疫苗可抑制肿瘤生长。低剂量（0.05 - 0.2毫克）的卡介苗诱导的抵抗力与皮下接种肿瘤细胞的效果相当，而高剂量（0.5 - 1.0毫克）则无效。预防性皮内注射卡介苗对MC 11和MC 12肿瘤的生长没有影响。
