Baldwin R W, Pimm M V
Br J Cancer. 1973 Jan;27(1):48-54. doi: 10.1038/bjc.1973.6.
Pulmonary growths produced by intravenous injection of methycholanthrene-induced sarcoma cells were controlled or suppressed by specific immunostimulation with BCG-sarcoma cell inocula at subcutaneous sites or by intravenous treatment with BCG alone. The response was dependent upon the immunogenicity of the treated tumour so that in comparison, intravenous injection of BCG enhanced rather than suppressed pulmonary growths of transferred cells of several weakly immunogenic tumours including a spontaneously arising sarcoma and an epithelioma as well as a carcinogen-induced mammary carcinoma.
通过静脉注射甲基胆蒽诱导的肉瘤细胞所产生的肺部肿瘤，可通过在皮下部位接种卡介苗 - 肉瘤细胞进行特异性免疫刺激，或仅通过静脉注射卡介苗来控制或抑制。这种反应取决于所治疗肿瘤的免疫原性，因此相比之下，静脉注射卡介苗增强而非抑制了几种弱免疫原性肿瘤转移细胞的肺部生长，这些肿瘤包括自发产生的肉瘤、上皮瘤以及致癌物诱导的乳腺癌。
