Marmigère Frédéric, Ernfors Patrik
Section of Molecular Neurobiology, Karolinska Institutet, MBB, Scheeles vg 1, S17 177 Stockholm, Sweden.
Nat Rev Neurosci. 2007 Feb;8(2):114-27. doi: 10.1038/nrn2057.
During the development of the nervous system, many different types of neuron are produced. As well as forming the correct type of neuron, each must also establish precise connections. Recent findings show that, because of shared gene programmes, neuronal identity is intimately linked to and coordinated with axonal behaviour. Peripheral sensory neurons provide an excellent system in which to study these interactions. This review examines how neuronal diversity is created in the PNS and describes proteins that help to direct the diversity of neuronal subtypes, cell survival, axonal growth and the establishment of central patterns of modality-specific connections.
在神经系统发育过程中，会产生许多不同类型的神经元。除了形成正确类型的神经元外，每个神经元还必须建立精确的连接。最近的研究结果表明，由于共享基因程序，神经元身份与轴突行为密切相关并相互协调。外周感觉神经元提供了一个研究这些相互作用的绝佳系统。本综述探讨了周围神经系统中神经元多样性是如何产生的，并描述了有助于指导神经元亚型多样性、细胞存活、轴突生长以及建立模式特异性连接的中枢模式的蛋白质。
