Olsen Sjúrdur Fródi, Mikkelsen Tina Broby, Knudsen Vibeke Kildegaard, Orozova-Bekkevold Ivanka, Halldórsson Thórhallur Ingi, Strøm Marin, Osterdal Marie Louise
Maternal Nutrition Group, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark.
Paediatr Perinat Epidemiol. 2007 Jan;21(1):76-86. doi: 10.1111/j.1365-3016.2007.00777.x.
Recent research suggests that the diet consumed in, or shortly before, pregnancy can potentially lead to maldevelopment and diseases in the offspring, which may become apparent at any time from the embryonic stage until old age. For example, maternal diet may affect the chance of twinning (and associated complications), malformation risk, brain development, and the offspring's fecundity and risk of contracting cardiovascular diseases and cancer in adult life. Prospectively designed longitudinal studies with sufficient size and data quality are much needed to substantiate or refute these hypotheses. At present, the Danish National Birth Cohort is likely to be the largest epidemiological database containing extensive information on maternal dietary exposures. By October 2002, 100 000 women had been recruited in early pregnancy, for long-term follow-up of themselves and their offspring. The present paper details the information available in the database on early nutritional exposures with emphasis on maternal dietary intake. We also present distributions of selected nutritional exposures.
近期研究表明，孕期或孕前摄入的饮食可能会导致后代发育不良和患病，这些影响可能在从胚胎期到老年的任何时候显现出来。例如，母亲的饮食可能会影响怀双胞胎的几率（以及相关并发症）、畸形风险、大脑发育，以及后代的生育能力和成年后患心血管疾病和癌症的风险。迫切需要进行规模足够大且数据质量高的前瞻性纵向研究来证实或反驳这些假设。目前，丹麦国家出生队列可能是最大的流行病学数据库，其中包含有关母亲饮食暴露的广泛信息。到2002年10月，已有10万名妇女在怀孕早期被招募，以便对她们自身及其后代进行长期随访。本文详细介绍了该数据库中有关早期营养暴露的可用信息，重点是母亲的饮食摄入情况。我们还展示了选定营养暴露的分布情况。
